routing traffic over wireguard with mikrotik to a specific ip address…

Routing traffic for a specific destination over the VPN is definitely much easier. After creating the VPN tunnel between two Mikrotik routers, it was a two-more step process:

/ip firewall nat
add action=masquerade chain=srcnat ipsec-policy=out,none out-interface=NAME-OF-WG-INTERFACE

/ip route
add distance=1 dst-address=ip.ip.ip.ip/32 gateway=IP-OF-WG-SERVER

Larger subnets than a single ip can be routed through the VPN, and multiple subnets can be routed too. The caveat for this simpler method is that you cannot route “all” traffic (ie. to 0.0.0.0) through the VPN, or else the client Mikrotik itself cannot route its own traffic either.